Wound healing
hideWound healing, or wound repair, is an intricate process in which the skin (or some other organ) repairs itself after injury. In normal skin, the epidermis (outermost layer) and dermis (inner or deeper layer) exists in a steady-stated equilibrium, forming a protective barrier against the external environment. Once the protective barrier is broken, the normal (physiologic) process of wound healing is immediately set in motion. The classic model of wound healing is divided into three or four sequential, yet overlapping, phases: (1) hemostasis (not considered a phase by some authors), (2) inflammatory, (3) proliferative and (4) remodeling.
Upon injury to the skin, a set of complex biochemical events takes place in a closely orchestrated cascade to repair the damage. Within minutes post-injury, platelets (thrombocytes) aggregate at the injury site to form a fibrin clot. This clot acts to control active bleeding (hemostasis).
In the inflammatory phase, bacteria and debris are phagocytized and removed, and factors are released that cause the migration and division of cells involved in the proliferative phase.
The proliferative phase is characterized by angiogenesis, collagen deposition, granulation tissue formation, epithelialization, and wound contraction. In angiogenesis, new blood vessels are formed by vascular endothelial cells. In fibroplasia and granulation tissue formation, fibroblasts grow and form a new, provisional extracellular matrix (ECM) by excreting collagen and fibronectin. Concurrently, re-epithelialization of the epidermis occurs, in which epithelial cells proliferate and 'crawl' atop the wound bed, providing cover for the new tissue.
In contraction, the wound is made smaller by the action of myofibroblasts, which establish a grip on the wound edges and contract themselves using a mechanism similar to that in smooth muscle cells. When the cells' roles are close to complete, unneeded cells undergo apoptosis.
In the maturation and remodeling phase, collagen is remodeled and realigned along tension lines and cells that are no longer needed are removed by apoptosis.
However, this process is not only complex but fragile, and susceptible to interruption or failure leading to the formation of chronic non-healing wounds. Factors which may contribute to this include diabetes, venous or arterial disease, old age, and infection.
For more information about Wound healing, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
News tagged with wound healing
Nanodiamonds deliver insulin for wound healing
Nanotechnology / Bio & Medicine
Jul 27, 2009 |
4.7 / 5 (7) |
7
(PhysOrg.com) -- Bacterial infection is a major health threat to patients with severe burns and other kinds of serious wounds such as traumatic bone fractures. Recent studies have identified an important new weapon for fighting ...
Researchers identify new stem cell
Dec 07, 2009 |
5 / 5 (6) |
0
(PhysOrg.com) -- Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage, and even nerve cells. These newly-described ...
Math used as a tool to heal toughest of wounds
Sep 21, 2009 |
5 / 5 (3) |
1
(PhysOrg.com) -- Scientists expect a new mathematical model of chronic wound healing could replace intuition with clear guidance on how to test treatment strategies in tackling a major public-health problem.
Enriched environment improves wound healing in rats
Medicine & Health / Psychology & Psychiatry
May 13, 2009 |
3.7 / 5 (3) |
1
Improving the environment in which rats are reared can significantly strengthen the physiological process of wound healing, according to a report in the online, open-access, peer-reviewed journal PLoS ONE.
Research yields potential target for cancer, wound healing and fibrosis
Mar 18, 2009 |
4 / 5 (1) |
0
Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists ...
Study Reveals New Role of Vitamin C in Skin Protection
Sep 09, 2009 |
4 / 5 (2) |
0
(PhysOrg.com) -- Scientists have uncovered a new role played by Vitamin C in protecting the skin.
New approach to wound healing may be easy on skin, but hard on bacteria
Aug 19, 2009 |
5 / 5 (3) |
0
In a presentation today (Aug. 19) to the American Chemical Society meeting, Ankit Agarwal, a postdoctoral researcher at the University of Wisconsin-Madison, described an experimental approach to wound healing that could take ...
How to make a lung: Cell-regeneration molecules essential signals for early lung development
Aug 17, 2009 |
not rated yet |
0
A tissue-repair-and-regeneration pathway in the human body, including wound healing, is essential for the early lung to develop properly. Genetically engineered mice fail to develop lungs when two molecules ...
Uncovering how cells cover gaps (w/ Video)
Jun 26, 2009 |
not rated yet |
0
Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, came a step closer to understanding how cells close gaps not only during embryonic development but also duringwound healing. ...
Scientists suspect omega-3 fatty acids could slow acute wound healing
Jul 23, 2008 |
3.7 / 5 (7) |
0
A recent study shows that popular fish oil supplements have an effect on the healing process of small, acute wounds in human skin. But whether that effect is detrimental, as researchers initially suspected, remains a mystery.
Licking your wounds: Scientists isolate compound in human saliva that speeds wound healing
Jul 23, 2008 |
4.8 / 5 (12) |
0
[B]New research in the FASEB Journal raises expectorations for people with chronic wounds[/B] A report by scientists from The Netherlands published online in The FASEB Journal identifies a compound in human saliva that great ...
Aggressive microdermabrasion induces wound-healing response in aging skin
Oct 19, 2009 |
not rated yet |
0
Microdermabrasion using a coarse diamond-studded instrument appears to induce molecular changes in the skin of older adults that mimic the way skin is remodeled during the wound healing process, according to a report in the ...
Advancement in tissue engineering promotes oral wound healing
Feb 03, 2009 |
4 / 5 (1) |
0
Oral tissue engineering for transplantation to aid wound healing in mouth (oral cavity) reconstruction has taken a significant step forward with a Netherlands-based research team's successful development of a gum tissue (gingival) ...
Plastic surgeons warn of malnutrition in body contouring patients
Nov 13, 2008 |
not rated yet |
0
Identifying malnutrition before surgery in massive weight loss patients seeking body contouring will significantly decrease surgical complications, accelerate wound healing, improve scar quality and boost patient energy levels, ...
