News tagged with p450
Genetic variation of enzyme linked with outcomes for women receiving tamoxifen
Oct 06, 2009 |
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Among women with early stage breast cancer, genetic variation of a certain enzyme appears to be associated with clinical outcomes for women treated with tamoxifen, according to a study in the October 7 issue of JAMA.
Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?
May 26, 2009 |
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Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by caffeic acid, an anti-inflammatory antioxidant compound ...
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A molecular switch turns on the flame in 'nature's blowtorch'
May 29, 2008 |
4.9 / 5 (7) |
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Uncontrolled reaction of organic compounds with oxygen is easy: we call it fire. But nature often needs to do oxidations very specifically, adding oxygen to a particular carbon atom in a complicated molecule without disturbing ...
Biochemists manipulate fruit flavor enzymes
Biology /
Aug 20, 2008 |
4.7 / 5 (3) |
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Would you like a lemony watermelon? How about a strawberry-flavored banana? Biochemists at The University of Texas Medical School at Houston say the day may be coming when scientists will be able to fine tune enzymes responsible ...
Revealing the workings of 'Mother Nature's blowtorch'
Biology /
Sep 13, 2007 |
4.6 / 5 (5) |
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Using atom-level imaging techniques, University of Michigan researchers have revealed important structural details of an enzyme system known as "Mother Nature's blowtorch" for its role in helping the body efficiently break ...
Team finds key mechanism of DDT resistance in malarial mosquitoes
Biology /
Jun 16, 2008 |
4.2 / 5 (5) |
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University of Illinois researchers have identified a key detoxifying protein in Anopheles mosquitoes that metabolizes DDT, a synthetic insecticide used since World War II to control the mosquitoes that spread ...
Researchers genetically engineer micro-organisms into tiny factories
Biology /
Sep 18, 2007 |
4.7 / 5 (10) |
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Microorganisms may soon be efficiently and inexpensively producing novel pharmaceutical compounds, such as flavonoids, that fight aging, cancer or obesity, as well as high-value chemicals, as the result of research being ...
Scientists ramp up ability of poplar plants to disarm toxic pollutants
Biology /
Oct 15, 2007 |
4.9 / 5 (8) |
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Scientists since the early '90s have seen the potential for cleaning up contaminated sites by growing plants able to take up nasty groundwater pollutants through their roots. Then the plants break certain ...
Developing enzymes to clean up pollution by explosives
Oct 09, 2009 |
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Scientists at the University of York have uncovered the structure of an unusual enzyme which can be used to reverse the contamination of land by explosives.
Powerful integration of lipid metabolic profiling with gene expression analysis
Biology /
Nov 05, 2007 |
5 / 5 (1) |
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A recently published research article in the Journal of Proteome Research, authored by researchers from the Nestlé Reserarch Center, Genomatix Software GmbH, Rosetta Inpharmatics LLC, CXR Biosciences Ltd, the Cancer Resear ...
What is the role of reactive oxygen species in ethanol-mediated cell death of polarized hepatic cells?
Jun 15, 2009 |
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Liver disease that results as a consequence of alcohol abuse is a major medical problem worldwide. Ethanol consumption leads to a variety of liver alterations including the accumulation of fat, inflammation of the liver, ...
Genetic testing not cost-effective in guiding initial dosing of common blood thinner
Jan 19, 2009 |
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New analyses led by the University of Cincinnati (UC) show that genetic testing used to guide initial dosing of the blood-thinner warfarin may not be cost-effective for typical patients with atrial fibrillation but may be ...
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