Researchers at the Novo Nordisk Foundation Center for Biosustainability in Denmark have developed a method of producing P450 enzymes used by plants to defend against predators and microbes in bacterial cell factories. The ...
Biotechnology
Jun 2, 2017
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Cytochrome P450 is a well-known family of enzymes that are involved in drug metabolism. The active site contains a heme chemical structure in which an iron atom is bound to the heme cofactor within the enzyme. The oxidation ...
Researchers working at the Department of Energy's SLAC National Accelerator Laboratory have discovered that a mere 9-trillionths-of-a-meter reduction in the length of a chemical bond dramatically boosts the reactivity of ...
Materials Science
Oct 8, 2015
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(Phys.org)—Cytochrome P450 (CYP) is sometimes referred to as the "Rosetta Stone" of iron-containing oxygenases, because of its ubiquity as a biocatalyst for various reactions, including drug metabolism and synthesis of ...
Natural enzymes are very clever molecular machines. They are the catalyst for many of nature's chemical transformations. And the conditions they need to perform their task are rather precisely defined. There is a need to ...
Biochemistry
Sep 27, 2013
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(Phys.org) —How our bodies break down the common drugs ibuprofen, diclofenac and warfarin is the subject of a new study from the University of Bristol, published in the Journal of the American Chemical Society. The research ...
Biochemistry
May 24, 2013
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Protein engineers at the California Institute of Technology (Caltech) have tapped into a hidden talent of one of nature's most versatile catalysts. The enzyme cytochrome P450 is nature's premier oxidation catalyst—a protein ...
Materials Science
Dec 20, 2012
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Larvae of the cotton bollworm (Helicoverpa armigera) are dreaded pests all over the world. They have a very wide host range: About 200 different plant species are known as potential food for the voracious insect. The herbivore ...
Biotechnology
Sep 12, 2012
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Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory are giving scientists unprecedented access to a key class of proteins involved in drug detoxification.
Biochemistry
Dec 6, 2011
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Many plants, including crops, release volatiles in response to insect attack. The chemical compounds can be a defense or can be an aromatic call for help to attract enemies of the attacking insect. Researchers from Virginia ...
Plants & Animals
Nov 15, 2010
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